Metastatic Breast Cancer
“Developments in the Treatment of Metastatic Triple Negative Breast Cancer,” with Dr. Sylvia Adams
“Metastatic Breast Cancer Awareness Day: A Special Event Webinar”
“Metastatic Breast Cancer: Cutting-Edge Research from the National Cancer Institute,” with Dr. Patricia Steeg
By Beth Kling - October 19, 2016
Sylvia Adams, MD, medical oncologist, and associate professor at the NYU School of Medicine, will discuss the latest research including the role of immunology in the treatment of triple negative metastatic breast cancer. This webinar was hosted on October 19, 2016.
By Beth Kling - October 13, 2016
Hear the recording and see the slides from this special webinar hosted on Metastatic Breast Cancer Awareness Day, October 13, 2016.
By Beth Kling - June 29, 2016
Dr. Maura Dickler, a board-certified medical oncologist at MSKCC will present news from the annual meeting of the American Society of Clinical Oncology (ASCO) as it relates to those living with metastatic breast cancer. Q&A period will follow. In collaboration with the Metastatic Breast Cancer Network.
By Melissa Sakow - March 1, 2016
In case you missed it, here's the recording of Dr. Tiffany Traina's highly-rated webinar presenting the latest research on metastatic breast cancer reported at the San Antonio Breast Cancer Symposium in December 2015. A Q&A followed. Dr. Traina is a medical oncologist at Memorial Sloan-Kettering Cancer Center.
By Beth Kling - June 15, 2015
Dr. Clifford Hudis of Memorial Sloan-Kettering Cancer Center (MSKCC) discusses recent developments in the treatment of metastatic breast cancer at a June 2015 gathering co-sponsored by SHARE, MSKCC, and the Metastatic Breast Cancer Network. If you missed his talk, listen here (he starts speaking after a 90-second introduction):
By Christine Benjamin - October 29, 2013
If you missed our webinar, "Managing Symptoms and Side Effects: How Caregivers Can Help," check out the video here. It starts a few slides in, but you'll get really valuable information anyway. The focus is on women with metastatic breast cancer.
By Beth Kling - October 16, 2014
Yesterday's webinar with Dr. Patricia Steeg related her approach to metastatic breast cancer research and talked about the development of experimental models of brain metastasis. If you didn't catch it live, you can watch the video above.
By Beth Kling - October 10, 2014
In last Monday's webinar, Dr. Don Dizon talked about "Coping with October." Those living with Metastatic Breast Cancer often struggle with additional negative feelings during Breast Cancer Awareness Month. Dr. Dizon speaks to women with MBC to offer encouragement and coping strategies specifically tailored for October-related issues. A video of this webinar is now available for you to watch here.
Dr. Matthew Ellis, Baylor College of Medicine, Houston, TX, provides a review of the research presented at SABCS 2016 specifically for MBC. This webinar is in collaboration with MBCN and Theresa's Research Foundation.
4:36 Dr. Matthew Ellis’s thoughts about Metastatic breast cancer
5:57 Breast cancer is caused by mutations (as we get older our cell DNA ages and mutations, or corruptions in the DNA, occur, and they can lead to cancer)
10: 11 “Landscape of somatic mutations in 560 breast cancer whole genome sequences” (scientific paper that attempts to document all the genetic variation in breast cancer across the 3 billion base pairs that makes up the human genome)
12:20 New drugs introduced into treatment of metastatic breast cancer in last year (drugs that target cell enzyme called Cyclin Dependent Kinase: Palbociclib, Abemaciclib, Ribociclib for er+ breast cancer)
14:04 Paloma-2 Trial (Palbociclib)
16:31 MonaLeesa-2 Trial (Ribociclib)
17:39 Belle-3 Trial (Buparlisib; PIK3CA; only works effectively when PI3 Kinase mutation is present. Drugs in this pathway could be helpful for patients with metastatic disease and similar drugs with fewer side effects are in clinical trials.)
19:15 New ways to define therapeutic targets
“Proteogenomics connects somatic mutations to signalling in breast cancer” (scientific paper)
21:40 Can we make the diagnosis of breast cancer mutations easier? (Need for tissue biopsies is difficult because metastatic disease is buried in organs.)
22:36 Cell free plasma tumor DNA in breast oncology: DNA circulates in the blood stream and gene sequences from a tumor can be identified through a simple blood test without the need for a tissue biopsy. (Digital PCR)
23:36 New studies in metastatic disease: ESR1 activating mutations cluster in the LBD
24:32 Falcon Study (Fulvestrant vs. anastrozole)
25:44 Can we harness the immune system to treat breast cancer?
26:17 Breast cancer immunotherapy: Building on clinical success (scientific paper)
26:26 Targeting the PD-1 Pathway in Breast Cancer
28:31 Breast Cancer Can Induce Adaptive Immune Responses
29:07 PD-1/PD-L1 Blockade in Breast Cancer
30:39 Can we involve more patients in metastatic breast cancer research? (MBC Project, mbcproject.org; challenges of studying patient tumor samples; patient-reported data)
36:23 Q&A: Which is the most promising research development for metastatic breast cancer announced at San Antonio Breast Cancer Symposium?
37:30 Q&A: Was anything presented about metastatic triple negative breast cancer other than immunotherapy at the San Antonio Breast Cancer Symposium?
39:21 Q&A: You mentioned cures for metastatic HER 2 positive breast cancer. Can you categorize the nature of the cure?
40:37 Q&A: In the slide you included about circulating cell-free DNA, were you referring to liquid biopsy? Is liquid biopsy being used in practice and are all liquid biopsies created equal?
44:18 Q&A: Is there research into whether drug holidays may help resistance?
45:51 Q&A: When is the best time to do genomic sequencing? Is genomic sequencing generally covered by insurance or Medicare?
49:20 Q&A: How can patients be connected to the clinical research community independent of big institutions?
53:20 Q&A: Was there anything reported about lobular metastatic breast cancer at the San Antonio Breast Cancer Symposium?
56:22 Q&A: A recent scientific article mentioned that mutations vary by the sites being biopsied. How do we decide which sites to biopsy?
57:49 Q&A: Can a drug or chemotherapy regimen that was used successfully and then failed be used again at a later date and be successful?
59:18 Q&A: Any diet recommendations?
SHARE Senior Director of Programs Ivis Febus-Sampayo on Novartis Drug for Metastatic Breast Cancer.