Understanding the Relationship Between Estrogen and Uterine Cancer

February 7, 2023

Estrogen can play a role in uterine cancer in a number of ways. Many uterine cancer tumor types are considered to be hormonally driven, especially endometrioid tumors. Obesity is a strong risk factor as it increases and produces additional estrogen levels in our bodies. Uterine cancer treatments are evolving, and today experts can treat estrogen related uterine cancers with some of the same therapies used to treat breast and ovarian cancer. Join Dr. Kristen Zeligs, Gynecologic Oncologist at Mt. Sinai Hospital, as she discusses these and other links between estrogen and uterine cancer. She will also review the latest treatment information as well as risk reduction strategies.

Key takeaways from webinar viewers:

• Having too much estrogen can cause an overgrowth of cells in the endometrium/uterine wall and can lead to an uterine cancer diagnosis.
• The use of progesterone can be used to treat early stage estrogen related uterine cancer.
• Taking low levels of estrogen helps alleviate menopausal side effects.
• Some of the same therapies that are being used to treat breast cancer such Trastuzumab and letrozole have been effective  in treating HER2 positive related endometrial cancer.

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